A dual role for EDEM1 in the processing of rod opsin.

  title={A dual role for EDEM1 in the processing of rod opsin.},
  author={Maria Kosmaoglou and Naheed Kanuga and M{\`o}nica Aguil{\`a} and Pere Garriga and Michael E Cheetham},
  journal={Journal of cell science},
  volume={122 Pt 24},
Mutations in rod opsin, the archetypal G-protein-coupled receptor, cause retinitis pigmentosa. The majority of mutations, e.g. P23H, cause protein misfolding, resulting in ER retention, induction of the unfolded protein response and degradation by ERAD. If misfolded rod opsin escapes degradation, it aggregates and forms intracellular inclusions. Therefore, it is important to identify the chaperones that mediate the folding or degradation of rod opsin. ER degradation enhancing alpha-mannosidase… CONTINUE READING