A dual regulatory role of cyclic adenosine monophosphate receptor protein in various virulence traits of Vibrio vulnificus.

@article{Kim2013ADR,
  title={A dual regulatory role of cyclic adenosine monophosphate receptor protein in various virulence traits of Vibrio vulnificus.},
  author={Young Ran Kim and Shee Eun Lee and Boa Kim and Hyon E Choy and Joon Haeng Rhee},
  journal={Microbiology and immunology},
  year={2013},
  volume={57 4},
  pages={273-80}
}
Vibrio vulnificus causes fatal septicemia in susceptible subjects after the ingestion of raw seafood. In the present study, the roles of cyclic adenosine monophosphate (cAMP) receptor protein (CRP) in V. vulnificus pathogenesis were investigated. A mutation in the V. vulnificus crp gene resulted in a significant down-regulation of various virulence phenotypes, except for RtxA1-mediated cytoskeletal rearrangement. Bacterial growth was impeded by the crp mutation. In addition, colony morphology… CONTINUE READING

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