A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials.

@article{Calloe2016ADP,
  title={A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials.},
  author={K Calloe and Jos{\'e} M. Di Diego and Rie Schultz Hansen and Shea A Nagle and Jacqueline A. Treat and Jonathan M. Cordeiro},
  journal={Biochemical pharmacology},
  year={2016},
  volume={108},
  pages={36-46}
}
BACKGROUND A loss of repolarization reserve due to downregulation of K(+) currents has been observed in cultured ventricular myocytes. A similar reduction of K(+) currents is well documented under numerous pathophysiological conditions. We examined the extent of K(+) current downregulation in cultured canine cardiac myocytes and determined whether a dual K(+) current activator can normalize K(+) currents and restore action potential (AP) configuration. METHODS AND RESULTS Ventricular myocytes… CONTINUE READING