A dual-pathway ultrastructural model for the tight junction of rat proximal tubule epithelium.

@article{Guo2003ADU,
  title={A dual-pathway ultrastructural model for the tight junction of rat proximal tubule epithelium.},
  author={Peng Guo and Alan M. Weinstein and Sheldon Weinbaum},
  journal={American journal of physiology. Renal physiology},
  year={2003},
  volume={285 2},
  pages={
          F241-57
        }
}
A dual-pathway model is proposed for transport across the tight junction (TJ) in rat proximal tubule: large slit breaks formed by infrequent discontinuities in the TJ complex and numerous small circular pores, with spacing similar to that of claudin-2. This dual-pathway model is developed in the context of a proximal tubule model (Weinstein AM. Am J Physiol Renal Fluid Electrolyte Physiol 247: F848-F862, 1984) to provide an ultrastructural view of solute and water fluxes. Tubule model paramters… 
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