A dual mechanism for regulation of kidney phosphate transport by parathyroid hormone.

@article{Cole1987ADM,
  title={A dual mechanism for regulation of kidney phosphate transport by parathyroid hormone.},
  author={Judith A. Cole and Sammy L. Eber and R E Poelling and Pamela K. Thorne and Leonard Ralph Forte},
  journal={The American journal of physiology},
  year={1987},
  volume={253 2 Pt 1},
  pages={
          E221-7
        }
}
Regulation of phosphate transport by parathyroid hormone (PTH) was investigated in continuous lines of kidney cells. Phosphate transport was reduced by PTH-(1-34) at physiological concentrations (EC50 5 X 10(-11) M), whereas much higher concentrations were required to stimulate cAMP formation (EC50 1 X 10(-8) M) in opossum kidney (OK) cells. The PTH analogue [Nle]PTH-(3-34) also inhibited phosphate transport but did not enhance cAMP formation. Instead, [Nle]PTH-(3-34) was a competitive… CONTINUE READING
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