A dual inhibition: microRNA-552 suppresses both transcription and translation of cytochrome P450 2E1.

Abstract

MicroRNAs (miRNAs) can direct post-transcriptional or transcriptional gene silencing. Here, we report that miR-552 is in the nucleus and cytosol and inhibits human cytochrome P450 (CYP) 2E1 expression at both transcriptional and post-transcriptional levels. MiR-552 via its non-seed sequence forms hybrids with a loop hairpin of the cruciform structure in… (More)
DOI: 10.1016/j.bbagrm.2016.02.016

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@article{Miao2016ADI, title={A dual inhibition: microRNA-552 suppresses both transcription and translation of cytochrome P450 2E1.}, author={Lingling Miao and Hailan Yao and Chenggang Li and Mengfan Pu and Xuan Yao and Hui Yang and Xinming Qi and Jin Ren and Yizheng Wang}, journal={Biochimica et biophysica acta}, year={2016}, volume={1859 4}, pages={650-62} }