A dual-emissive-materials design concept enables tumour hypoxia imaging.

@article{Zhang2009ADD,
  title={A dual-emissive-materials design concept enables tumour hypoxia imaging.},
  author={Guoqing Zhang and Gregory M. Palmer and Mark W. Dewhirst and Cassandra L Fraser},
  journal={Nature materials},
  year={2009},
  volume={8 9},
  pages={747-51}
}
Luminescent materials are widely used for imaging and sensing owing to their high sensitivity, rapid response and facile detection by many optical technologies. Typically materials must be chemically tailored to achieve intense, photostable fluorescence, oxygen-sensitive phosphorescence or dual emission for ratiometric sensing, often by blending two dyes in a matrix. Dual-emissive materials combining all of these features in one easily tunable molecular platform are desirable, but when… CONTINUE READING

5 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Dual - emissive materials combining all of these features in one easily tunable molecular platform are desirable , but when fluorescence and phosphorescence originate from the same dye , it can be challenging to vary relative fluorescence / phosphorescence intensities for practical sensing applications .
Dual - emissive materials combining all of these features in one easily tunable molecular platform are desirable , but when fluorescence and phosphorescence originate from the same dye , it can be challenging to vary relative fluorescence / phosphorescence intensities for practical sensing applications .
We demonstrate the versatility of this approach by showing that films made from low - molecular - weight BF(2)dbm(I)PLA with weak fluorescence and strong phosphorescence are promising as ' turn on ' sensors for aerodynamics applications , and that nanoparticles fabricated from a higher - molecular - weight polymer with balanced fluorescence and phosphorescence intensities serve as ratiometric tumour hypoxia imaging agents .
We demonstrate the versatility of this approach by showing that films made from low - molecular - weight BF(2)dbm(I)PLA with weak fluorescence and strong phosphorescence are promising as ' turn on ' sensors for aerodynamics applications , and that nanoparticles fabricated from a higher - molecular - weight polymer with balanced fluorescence and phosphorescence intensities serve as ratiometric tumour hypoxia imaging agents .
We demonstrate the versatility of this approach by showing that films made from low - molecular - weight BF(2)dbm(I)PLA with weak fluorescence and strong phosphorescence are promising as ' turn on ' sensors for aerodynamics applications , and that nanoparticles fabricated from a higher - molecular - weight polymer with balanced fluorescence and phosphorescence intensities serve as ratiometric tumour hypoxia imaging agents .
We demonstrate the versatility of this approach by showing that films made from low - molecular - weight BF(2)dbm(I)PLA with weak fluorescence and strong phosphorescence are promising as ' turn on ' sensors for aerodynamics applications , and that nanoparticles fabricated from a higher - molecular - weight polymer with balanced fluorescence and phosphorescence intensities serve as ratiometric tumour hypoxia imaging agents .
Dual - emissive materials combining all of these features in one easily tunable molecular platform are desirable , but when fluorescence and phosphorescence originate from the same dye , it can be challenging to vary relative fluorescence / phosphorescence intensities for practical sensing applications .
Dual - emissive materials combining all of these features in one easily tunable molecular platform are desirable , but when fluorescence and phosphorescence originate from the same dye , it can be challenging to vary relative fluorescence / phosphorescence intensities for practical sensing applications .
Here , we report a strategy for modulating fluorescence / phosphorescence for a single - component , dual - emissive , iodide - substituted difluoroboron dibenzoylmethane - poly(lactic acid ) ( BF(2)dbm(I)PLA ) solid - state sensor material .
Typically materials must be chemically tailored to achieve intense , photostable fluorescence , oxygen - sensitive phosphorescence or dual emission for ratiometric sensing , often by blending two dyes in a matrix .
Typically materials must be chemically tailored to achieve intense , photostable fluorescence , oxygen - sensitive phosphorescence or dual emission for ratiometric sensing , often by blending two dyes in a matrix .
Dual - emissive materials combining all of these features in one easily tunable molecular platform are desirable , but when fluorescence and phosphorescence originate from the same dye , it can be challenging to vary relative fluorescence / phosphorescence intensities for practical sensing applications .
Dual - emissive materials combining all of these features in one easily tunable molecular platform are desirable , but when fluorescence and phosphorescence originate from the same dye , it can be challenging to vary relative fluorescence / phosphorescence intensities for practical sensing applications .
We demonstrate the versatility of this approach by showing that films made from low - molecular - weight BF(2)dbm(I)PLA with weak fluorescence and strong phosphorescence are promising as ' turn on ' sensors for aerodynamics applications , and that nanoparticles fabricated from a higher - molecular - weight polymer with balanced fluorescence and phosphorescence intensities serve as ratiometric tumour hypoxia imaging agents .
We demonstrate the versatility of this approach by showing that films made from low - molecular - weight BF(2)dbm(I)PLA with weak fluorescence and strong phosphorescence are promising as ' turn on ' sensors for aerodynamics applications , and that nanoparticles fabricated from a higher - molecular - weight polymer with balanced fluorescence and phosphorescence intensities serve as ratiometric tumour hypoxia imaging agents .
Here , we report a strategy for modulating fluorescence / phosphorescence for a single - component , dual - emissive , iodide - substituted difluoroboron dibenzoylmethane - poly(lactic acid ) ( BF(2)dbm(I)PLA ) solid - state sensor material .
We demonstrate the versatility of this approach by showing that films made from low - molecular - weight BF(2)dbm(I)PLA with weak fluorescence and strong phosphorescence are promising as ' turn on ' sensors for aerodynamics applications , and that nanoparticles fabricated from a higher - molecular - weight polymer with balanced fluorescence and phosphorescence intensities serve as ratiometric tumour hypoxia imaging agents .
We demonstrate the versatility of this approach by showing that films made from low - molecular - weight BF(2)dbm(I)PLA with weak fluorescence and strong phosphorescence are promising as ' turn on ' sensors for aerodynamics applications , and that nanoparticles fabricated from a higher - molecular - weight polymer with balanced fluorescence and phosphorescence intensities serve as ratiometric tumour hypoxia imaging agents .
Dual - emissive materials combining all of these features in one easily tunable molecular platform are desirable , but when fluorescence and phosphorescence originate from the same dye , it can be challenging to vary relative fluorescence / phosphorescence intensities for practical sensing applications .
Dual - emissive materials combining all of these features in one easily tunable molecular platform are desirable , but when fluorescence and phosphorescence originate from the same dye , it can be challenging to vary relative fluorescence / phosphorescence intensities for practical sensing applications .
All Topics