A dual-Ca2+-sensor model for neurotransmitter release in a central synapse

@article{Sun2007ADM,
  title={A dual-Ca2+-sensor model for neurotransmitter release in a central synapse},
  author={Jianyuan Sun and Zhiping P Pang and Dengkui Qin and Abigail T. Fahim and Roberto Adachi and Thomas C S{\"u}dhof},
  journal={Nature},
  year={2007},
  volume={450},
  pages={676-682}
}
Ca2+-triggered synchronous neurotransmitter release is well described, but asynchronous release—in fact, its very existence—remains enigmatic. Here we report a quantitative description of asynchronous neurotransmitter release in calyx-of-Held synapses. We show that deletion of synaptotagmin 2 (Syt2) in mice selectively abolishes synchronous release, allowing us to study pure asynchronous release in isolation. Using photolysis experiments of caged Ca2+, we demonstrate that asynchronous release… CONTINUE READING
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