A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity.

@article{Circosta1984ADU,
  title={A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity.},
  author={C Circosta and Francesco Occhiuto and Salvatore Ragusa and A Trovato and Giovanni Tumino and F S Briguglio and Anna De Pasquale},
  journal={Journal of ethnopharmacology},
  year={1984},
  volume={11 3},
  pages={259-74}
}
In conscious normotensive rats the dried crude methanolic extract of Harpagophytum procumbens secondary roots caused a significant dose-dependent reduction of arterial blood pressure. The decrease was significant only at higher doses given by gavage (dried extract = 400 mg/kg). At the same time a decrease of heart rate was observed. In the same experimental conditions, harpagoside presented an activity lower than doses of Harpagophytum procumbens extract containing corresponding quantities of… CONTINUE READING