A double-switch vector system positively regulates transgene expression by endogenous microRNA expression (miR-ON vector).

@article{Amendola2013ADV,
  title={A double-switch vector system positively regulates transgene expression by endogenous microRNA expression (miR-ON vector).},
  author={Mario Amendola and Alice Giustacchini and Bernhard Gentner and Luigi Naldini},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2013},
  volume={21 5},
  pages={934-46}
}
To better understand and exploit microRNA (miR) regulation, a more precise characterization of miR expression patterns within a tissue or a lineage during development, differentiation, and homeostasis is needed. We previously showed that lentiviral vectors (LV) can be made responsive to miR to stringently control transgene expression as well as to report miR activity "live" and at the single-cell level. Although very useful, this approach reports miR activity by transgene suppression, hampering… CONTINUE READING
13 Citations
57 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Similar Papers

Loading similar papers…