A double mutation in the extracellular Ca2+-sensing receptor's venus flytrap domain that selectively disables L-amino acid sensing.

@article{Mun2005ADM,
  title={A double mutation in the extracellular Ca2+-sensing receptor's venus flytrap domain that selectively disables L-amino acid sensing.},
  author={Hee-chang Mun and Emma L Culverston and Alison H. Franks and Charles A. Collyer and Roderick John Clifton-Bligh and Arthur D. Conigrave},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 32},
  pages={29067-72}
}
The extracellular Ca(2+)-sensing receptor is activated allosterically by l-amino acids, and recent molecular analysis indicates that amino acids are likely to bind in the receptor's Venus flytrap domain. In the current study we set out to identify residues in the VFT domain that specifically support amino acid binding and/or amino acid-dependent receptor… CONTINUE READING