A double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal

@article{Corvera1994ADL,
  title={A double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal},
  author={Silvia Corvera and Anil Kumar Chawla and Ratna Chakrabarti and M C Joly and Joanne Buxton and M. Czech},
  journal={The Journal of Cell Biology},
  year={1994},
  volume={126},
  pages={1625 - 1625}
}
The unique COOH-terminal 30-amino acid region of the adipocyte/skeletal muscle glucose transporter (GLUT4) appears to be a major structural determinant of this protein's perinuclear localization, from where it is redistributed to the cell surface in response to insulin. To test whether an underlying mechanism of this domain's function involves glucose transporter endocytosis rates, transfected cells were generated expressing exofacial hemagglutinin epitope (HA)-tagged erythrocyte/brain glucose… CONTINUE READING

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Insulinsensitive association of GL UT-4 with endocytotic clathrin-coated vesicles revealed with the use of Brefeldin A

  • R. Chakrabarfi, J. Bexton, M. Joly, S. Corvera
  • J. Biol
  • 1994
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