A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents.

@article{Gray2012ADR,
  title={A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents.},
  author={Kevin M. Gray and Matthew J. Carpenter and Nathaniel L. Baker and Stacia M DeSantis and Elisabeth Kryway and Karen J. Hartwell and Aimee L. McRae‐Clark and Kathleen T. Brady},
  journal={The American journal of psychiatry},
  year={2012},
  volume={169 8},
  pages={
          805-12
        }
}
OBJECTIVE Preclinical findings suggest that the over-the-counter supplement N-acetylcysteine (NAC), via glutamate modulation in the nucleus accumbens, holds promise as a pharmacotherapy for substance dependence. The authors investigated NAC as a novel cannabis cessation treatment in adolescents, a vulnerable group for whom existing treatments have shown limited efficacy. METHOD In an 8-week double-blind randomized placebo-controlled trial, treatment-seeking cannabis-dependent adolescents… 

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