A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents.

@article{Gray2012ADR,
  title={A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents.},
  author={Kevin M Gray and Matthew J Carpenter and Nathaniel L. Baker and Stacia M DeSantis and Elisabeth Kryway and Karen J. Hartwell and Aimee L. McRae-Clark and Kathleen T. Brady},
  journal={The American journal of psychiatry},
  year={2012},
  volume={169 8},
  pages={
          805-12
        }
}
OBJECTIVE Preclinical findings suggest that the over-the-counter supplement N-acetylcysteine (NAC), via glutamate modulation in the nucleus accumbens, holds promise as a pharmacotherapy for substance dependence. The authors investigated NAC as a novel cannabis cessation treatment in adolescents, a vulnerable group for whom existing treatments have shown limited efficacy. METHOD In an 8-week double-blind randomized placebo-controlled trial, treatment-seeking cannabis-dependent adolescents… Expand
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TLDR
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TLDR
This study was designed to replicate positive findings from a study in cannabis-dependent adolescents that found greater odds of abstinence with NAC compared to PBO, and will assess the cannabis cessation efficacy of NAC combined with a behavioral intervention in adults, providing a novel and timely contribution to the evidence base for the treatment of cannabis use disorders. Expand
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References

SHOWING 1-10 OF 35 REFERENCES
Dronabinol for the treatment of cannabis dependence: a randomized, double-blind, placebo-controlled trial.
TLDR
Dronabinol showed promise, it was well-tolerated, and improved treatment retention and withdrawal symptoms, and this is the first trial using an agonist substitution strategy for treatment of cannabis dependence. Expand
An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: A pilot study
TLDR
Overall the findings suggest that it is feasible to treat cocaine-dependent treatment seekers with N-acetylcysteine on an outpatient basis. Expand
N-acetylcysteine (NAC) in young marijuana users: an open-label pilot study.
TLDR
The purpose of this open-label study was to gather tolerability and preliminary efficacy data for NAC in the treatment of cannabis dependence in young people, and to implicate NAC as a potential treatment for addictive disorders, including cannabis dependence. Expand
Is cocaine desire reduced by N-acetylcysteine?
TLDR
The inhibition of cocaine cue reactivity is consistent with existing preclinical data and supports the use of N-acetylcysteine as a treatment for cocaine dependence. Expand
Bupropion SR and contingency management for adolescent smoking cessation.
TLDR
Combined bupropion SR and CM appears efficacious, at least in the short-term, for adolescent smoking cessation and may be superior to either intervention alone. Expand
N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action.
TLDR
N-acetylcysteine has shown promising results in populations with these disorders, including those in whom treatment efficacy has previously been limited, and the therapeutic potential of this acetylated amino acid is beginning to emerge in the field of psychiatric research. Expand
The Cannabis Youth Treatment (CYT) Study: main findings from two randomized trials.
TLDR
Overall, the clinical outcomes were very similar across sites and conditions; however, after controlling for initial severity, the most cost-effective interventions were MET/CBT5 and MET-CBT12 in Trial 1 and ACRA and MET/ CBT5 in Trial 2. Expand
A randomized trial of contingency management for adolescent marijuana abuse and dependence.
TLDR
The outcomes observed in the experimental condition suggest that integrating CM abstinence-based approaches with other empirically based outpatient interventions provides an alternative and efficacious treatment model for adolescent substance abuse/dependence. Expand
The Role of Cystine-Glutamate Exchange in Nicotine Dependence in Rats and Humans
TLDR
Results indicate that the cystine-glutamate exchanger and the glial glutamate transporter are downregulated after nicotine self-administration, and augmenting exchanger activity with N-acetylcysteine reduced the number of cigarettes smoked in nicotine-dependent individuals. Expand
Evidence-Based Psychosocial Treatments for Adolescent Substance Abuse
  • H. Waldron, C. Turner
  • Psychology, Medicine
  • Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
  • 2008
TLDR
A number of other models are probably efficacious, and none of the treatment approaches appeared to be clearly superior to any others in terms of treatment effectiveness for adolescent substance abuse. Expand
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