A double-blind placebo-controlled case study of the use of donepezil to improve cognition in a schizoaffective disorder patient: functional MRI correlates.

@article{Risch2001ADP,
  title={A double-blind placebo-controlled case study of the use of donepezil to improve cognition in a schizoaffective disorder patient: functional MRI correlates.},
  author={Samuel C. Risch and Susan Regina McGurk and Michael David Horner and Ziad Nahas and Susan D Owens and Michael Molloy and Claude Gilliard and Samantha Christie and John Seth Markowitz and C Lindsay Devane and Jacobo E. Mintzer and Mark S. George},
  journal={Neurocase},
  year={2001},
  volume={7 2},
  pages={105-10}
}
Cognitive impairment in multiple domains is common in patients with schizophrenia and may be a powerful determinant of poor functional ability and quality of life. We report a double-blind, placebo-controlled, cross-over study of donepezil augmentation in a schizoaffective disorder patient stabilized on olanzapine pharmacotherapy. The patient showed significant improvements in several cognitive measures and increased activation of prefrontal cortex and basal ganglia on functional MRI during the… CONTINUE READING

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