A double blind comparison of zimelidine and amitriptyline in endogenous depression.

@article{Montgomery1981ADB,
  title={A double blind comparison of zimelidine and amitriptyline in endogenous depression.},
  author={Stuart A. Montgomery and Robert McAuley and Sujana Rani and Deeptarka Roy and David B. Montgomery},
  journal={Acta psychiatrica Scandinavica. Supplementum},
  year={1981},
  volume={290},
  pages={314-27}
}
In a randomized double-blind group comparison study of 40 patients with endogenous depression zimelidine appeared to be as effective an antidepressant as amitriptyline at 4 and 6 weeks using the Hamilton Rating Scale (HRS) and the Montgomery and Asberg Depression Rating Scale (MADRS). At 2 weeks there was a significantly better response (P less than 0.05) on zimelidine compared to amitriptyline on the clinician's global scale and 4 out of 10 items on the MADRS suggesting an early onset of… CONTINUE READING

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