A double-blind comparison of the gastroduodenal safety and efficacy of diclofenac and a fixed dose combination of diclofenac and misoprostol in the treatment of rheumatoid arthritis.

@article{Verdickt1992ADC,
  title={A double-blind comparison of the gastroduodenal safety and efficacy of diclofenac and a fixed dose combination of diclofenac and misoprostol in the treatment of rheumatoid arthritis.},
  author={W. Verdickt and C{\'e}sar A. Moran and H Hantzschel and Andrea M. A. Fraga and Helen Stead and George S. Geis},
  journal={Scandinavian journal of rheumatology},
  year={1992},
  volume={21 2},
  pages={
          85-91
        }
}
This double-blind, parallel group study was conducted to evaluate the gastroduodenal safety and antiarthritic efficacy of a fixed combination of diclofenac sodium 50 mg and misoprostol 200 mcg, compared with a combination of diclofenac 50 mg and placebo. Three hundred and thirty-nine patients with rheumatoid arthritis and no significant gastric or duodenal mucosal damage were enrolled and received study medication (diclofenac/misoprostol, 164; diclofenac/placebo, 175) BID or TID for 12 weeks… CONTINUE READING
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