A double-blind comparison of clomipramine and desipramine treatment of severe onychophagia (nail biting).

@article{Leonard1991ADC,
  title={A double-blind comparison of clomipramine and desipramine treatment of severe onychophagia (nail biting).},
  author={Henrietta L. Leonard and Marge C Lenane and Susan E. Swedo and David C Rettew and Judith L. Rapoport},
  journal={Archives of general psychiatry},
  year={1991},
  volume={48 9},
  pages={821-7}
}
Twenty-five adult subjects with severe morbid onychophagia (nail biting) and no history of obsessive-compulsive disorder were enrolled in a 10-week double-blind cross-over trial of clomipramine hydrochloride and desipramine hydrochloride. For the 14 subjects who completed the study, clomipramine hydrochloride (mean +/- SD dose, 120 +/- 48 mg/d) was superior to desipramine hydrochloride (mean +/- SD dose, 135 +/- 53 mg/d) in decreasing nail biting as measured by a repeated-measures analysis of… CONTINUE READING

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