A double-blind, randomized trial of topiramate in Lennox–Gastaut syndrome

@article{Sachdeo1999ADR,
  title={A double-blind, randomized trial of topiramate in Lennox–Gastaut syndrome},
  author={Rajesh C. Sachdeo and Terry Ann Glauser and Frank J. Ritter and R A Reife and Pilar C. Lim and Gordon W. Pledger},
  journal={Neurology},
  year={1999},
  volume={52},
  pages={1882 - 1882}
}
Objective: To evaluate the efficacy and safety of topiramate as adjunctive therapy for Lennox–Gastaut syndrome in a multicenter, double-blind, placebo-controlled trial. Background: Conventional antiepileptic drugs are frequently ineffective against multiple-seizure types of Lennox–Gastaut syndrome. Methods: Ninety-eight patients >1 year to <30 years of age, with slow spike-and-wave patterns on EEG, seizure types including drop attacks, and either a history of or active atypical absence seizures… Expand
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