A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder.

@article{Pancheri2002ADR,
  title={A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder.},
  author={P. Pancheri and P. Scapicchio and R. D. Chiaie},
  journal={The international journal of neuropsychopharmacology},
  year={2002},
  volume={5 4},
  pages={
          287-94
        }
}
S-adenosyl-L-methionine (SAMe) is a natural substance which constitutes the most important methyl donor in transmethylation reactions in the central nervous system. Several clinical trials have shown that SAMe possesses an antidepressant activity. This multicentre study was carried out to confirm both efficacy and safety of SAMe in the treatment of major depression. SAMe was given intramuscularly (i.m.) at a dose of 400 mg/d, double-blind, vs. 150 mg/d oral Imipramine (IMI) in patients with a… Expand
45 Citations
A double-blind, randomised, controlled clinical trial of acetyl-l-carnitine vs. amisulpride in the treatment of dysthymia
  • 76
  • PDF
A comprehensive review on the efficacy of S-Adenosyl-L-methionine in Major Depressive Disorder.
  • 29
S-adenosyl-methionine in depression: A comprehensive review of the literature
  • 83
  • PDF
S-adenosyl methionine (SAMe) for depression in adults.
  • 37
  • PDF
SAMe use in children and adolescents
  • 13
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 48 REFERENCES
Double-blind, placebo-controlled study of S-adenosyl-L-methionine in depressed postmenopausal women.
  • 56
Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial.
  • 130
  • Highly Influential
S-adenosylmethionine treatment of depression: a controlled clinical trial.
  • 100
  • Highly Influential
S‐adenosylmethionine blood levels in major depression: changes with drug treatment
  • 66
Influence of SAMe on the modifications of brain polyamine levels in an animal model of depression
  • 40
S‐adenosyl‐l‐methionine (SAMe) as antidepressant: meta‐analysis of clinical studies
  • G. Bressa
  • Medicine
  • Acta neurologica Scandinavica. Supplementum
  • 1994
  • 183
Influence of S‐adenosyl‐L‐methionine on chronic mild stress‐induced anhedonia in castrated rats
  • 65
...
1
2
3
4
5
...