A double-blind, randomized, placebo-controlled trial of divalproex extended-release in the treatment of bipolar disorder in children and adolescents.

@article{Wagner2009ADR,
  title={A double-blind, randomized, placebo-controlled trial of divalproex extended-release in the treatment of bipolar disorder in children and adolescents.},
  author={Karen Dineen Wagner and Laura Redden and Robert Kowatch and Timothy E Wilens and Scott Segal and Kiki D. Chang and Patricia Wozniak and Namita V Vigna and Walid Michel Abi-Saab and Mario Saltarelli},
  journal={Journal of the American Academy of Child and Adolescent Psychiatry},
  year={2009},
  volume={48 5},
  pages={519-32}
}
OBJECTIVE To compare the efficacy and safety of divalproex extended-release (ER) to placebo in a 28-day double-blind study of bipolar disorder in children and adolescents and evaluate the safety of divalproex ER in a 6-month open-label extension study. METHOD In the double-blind study, 150 patients (manic or mixed episode, aged 10-17 years) with baseline Young Mania Rating Scale (YMRS) score of 20 or higher were randomized to once-daily placebo or divalproex ER, which was titrated to clinical… CONTINUE READING

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