A double-blind, randomized, fixed-dose trial of fluoxetine vs. amitriptyline in the treatment of major depression complicating Alzheimer's disease.

@article{Taragano1997ADR,
  title={A double-blind, randomized, fixed-dose trial of fluoxetine vs. amitriptyline in the treatment of major depression complicating Alzheimer's disease.},
  author={Fernando Emilio Taragano and Constantine G Lyketsos and Carlos Alberto Mangone and Ricardo Francisco Allegri and E Comesa{\~n}a-Diaz},
  journal={Psychosomatics},
  year={1997},
  volume={38 3},
  pages={
          246-52
        }
}
The objective of this study was to determine the relative efficacy and safety of fluoxetine and amitriptyline in the treatment of major depression complicating Alzheimer's disease (AD). The sample included 37 patients with AD and major depression. The study design was a double-blind, fixed-dose, randomized clinical trial with 45 days of follow-up. The outcome measures were the Hamilton Depression Rating Scale (Ham-D), the Mini-Mental State Exam (MMSE), and the number of dropouts from each arm… CONTINUE READING
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