A double-blind, placebo-controlled trial of extract of Ginkgo biloba added to haloperidol in treatment-resistant patients with schizophrenia.

  title={A double-blind, placebo-controlled trial of extract of Ginkgo biloba added to haloperidol in treatment-resistant patients with schizophrenia.},
  author={Xiang Zhang and D. F. Zhou and P. Zhang and G Y Wu and Jian-min Su and Lian Yuan Cao},
  journal={The Journal of clinical psychiatry},
  volume={62 11},
BACKGROUND Many studies have indicated that excess free radical formation may be involved in the pathogenesis of patients with schizophrenia. Some investigators suggested that the use of free radical scavengers might provide improvement in schizophrenia. The aim of this study was to determine the effectiveness and to evaluate the side effects of extract of Ginkgo biloba (EGb) plus haloperidol in chronic, treatment-resistant inpatients with schizophrenia. METHOD One hundred nine patients… Expand
A placebo-controlled study of extract of ginkgo biloba added to clozapine in patients with treatment-resistant schizophrenia
Preliminary data suggested that EGb was found useful for enhancing the effect of clozapine on negative symptoms in patients with treatment-resistant schizophrenia. Expand
The effects of Ginkgo biloba extract added to haloperidol on peripheral T cell subsets in drug-free schizophrenia: a double-blind, placebo-controlled trial
The beneficial effects of EGb on the immune systems and the improvement of schizophrenic symptoms may be medicated through its antioxidant activity. Expand
Extract of Ginkgo biloba added to haloperidol was effective for positive symptoms in refractory schizophrenia
  • M. Knable
  • Medicine
  • Evidence-based mental health
  • 2002
A double-blind, placebo-controlled trial of extract of Ginkgo biloba added to haloperidol in treatment-resistant patients with schizophrenia and its implications for patients with chronic, refractory schizophrenia. Expand
Efficacy and safety of extract of Ginkgo biloba as an adjunct therapy in chronic schizophrenia: A systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis
The result showed that EGb had a significant difference in ameliorating total and negative symptoms of chronic schizophrenia as an adjuvant therapy to antipsychotics and the EGb therapy plus antipsychotic might be more efficacious. Expand
Extract of Ginkgo biloba treatment for tardive dyskinesia in schizophrenia: a randomized, double-blind, placebo-controlled trial.
EGb-761 appears to be an effective treatment for reducing the symptoms of TD in schizophrenia patients, and improvement may be mediated through the well-known antioxidant activity of this extract. Expand
Beneficial effects of ondansetron as an adjunct to haloperidol for chronic, treatment-resistant schizophrenia: A double-blind, randomized, placebo-controlled study
Ondansetron is an effective adjunctive agent in enhancing the effectiveness and reducing some adverse side effects of antipsychotic therapy for chronic, treatment-resistant schizophrenia, particularly for negative and cognitive symptoms. Expand
It is suggested that the use of Ginkgo biloba as an adjunct to Respridone and Biperiden was more effective than Risperidone withBiperiden regimen improving psychological condition of chronic schizophrenic patients. Expand
Effect of herbal and nutritional products on the central nervous system effects of haloperidol: a systematic review
Haloperidol is widely used in treatments of acute and chronic schizophrenia. Due to the narrow therapeutic window of haloperidol and the increasing popularity of herbal and nutritional productsExpand
Review and meta-analysis of usage of ginkgo as an adjunct therapy in chronic schizophrenia.
The roles of antioxidants in the pathophysiology of schizophrenia, whether the properties of ginkgo can ameliorate symptoms of this illness, and available literature to test this assumption are reviewed are reviewed. Expand
An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients with Schizophrenia
  • A. Shiina, N. Kanahara, +6 authors K. Hashimoto
  • Medicine
  • Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2015
Sulforaphane extracted from broccoli sprout is an agent with potent anti-oxidant and anti-inflammatory activity that has the potential to improve cognitive function in patients with schizophrenia. Expand