A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. Lamictal 614 Study Group.

@article{Calabrese2000ADP,
  title={A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. Lamictal 614 Study Group.},
  author={Joseph R. Calabrese and Trisha Suppes and Charles L. Bowden and Gary S. Sachs and Alan C. Swann and Susan L McElroy and Vivek Kusumakar and John A Ascher and Nancy L Earl and Peter Lawrence Greene and Eileen T Monaghan},
  journal={The Journal of clinical psychiatry},
  year={2000},
  volume={61 11},
  pages={841-50}
}
BACKGROUND Patients with rapid-cycling bipolar disorder are often treatment refractory. This study examined lamotrigine as maintenance monotherapy for rapid-cycling bipolar disorder. METHOD Lamotrigine was added to patients' current psychotropic regimens and titrated to clinical effect during an open-label treatment phase. Stabilized patients were tapered off other psychotropics and randomly assigned to lamotrigine or placebo monotherapy for 6 months. Time to additional pharmacotherapy for… CONTINUE READING

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