A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder.

@article{Arnold2004ADM,
  title={A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder.},
  author={Lesley M. Arnold and Yili Lu and Leslie J. Crofford and Madelaine M. Wohlreich and Michael J. Detke and Smriti Iyengar and David John Goldstein},
  journal={Arthritis and rheumatism},
  year={2004},
  volume={50 9},
  pages={2974-84}
}
OBJECTIVE To assess the efficacy and safety of duloxetine, a serotonin and norepinephrine reuptake inhibitor, in subjects with primary fibromyalgia, with or without current major depressive disorder. METHODS This study was a randomized, double-blind, placebo-controlled trial conducted in 18 outpatient research centers in the US. A total of 207 subjects meeting the American College of Rheumatology criteria for primary fibromyalgia were enrolled (89% female, 87% white, mean age 49 years, 38… CONTINUE READING
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