A double‐blind randomized controlled trial of antenatal mebendazole to reduce low birthweight in a hookworm‐endemic area of Peru

  title={A double‐blind randomized controlled trial of antenatal mebendazole to reduce low birthweight in a hookworm‐endemic area of Peru},
  author={Ren{\'e}e Larocque and Martin Casapia and Eduardo Gotuzzo and J. Dick Maclean and Julio C. Soto and Elham Rahme and Theresa W Gyorkos},
  journal={Tropical Medicine \& International Health},
Objective  To assess the effect on birthweight of antenatal mebendazole plus iron vs. placebo plus iron in a highly hookworm‐endemic area. 

Trichuris and hookworm infections associated with anaemia during pregnancy

The intensity of soil‐transmitted helminth (STH) infection and haemoglobin/anaemia and the effect of mebendazole treatment on the occurrence of STH infection are assessed.

Maternal Deworming Research Study (MADRES) protocol: a double-blind, placebo-controlled randomised trial to determine the effectiveness of deworming in the immediate postpartum period

A single-centre, parallel, double-blind, randomised, placebo-controlled trial will be carried out in Iquitos, Peru, to assess the effectiveness of integrating single-dose 400 mg albendazole into routine maternal postpartum care.

A Double-Blind Randomized Controlled Trial of Maternal Postpartum Deworming to Improve Infant Weight Gain in the Peruvian Amazon

The benefits of maternal postpartum deworming should be further investigated in study populations having higher overall prevalences and intensities of STH infections and, in particular, where whipworm and hookworm infections are of public health concern.

Antenatal Deworming and Materno-Perinatal Outcomes in Calabar, Nigeria

Presumptive deworming during the antenatal period can significantly reduce the incidence of peripartum anaemia, however, more studies may be needed to prove any positive perinatal outcome.

The Effect of Deworming on Growth in One-Year-Old Children Living in a Soil-Transmitted Helminth-Endemic Area of Peru: A Randomized Controlled Trial

The effect of deworming on growth could be detected in this population of preschool-age children in Iquitos, Peru with one year of follow-up, and there was no statistically significant difference in weight gain in any of the de worming intervention groups compared to the control group.

Malaria in pregnancy: the difficulties in measuring birthweight

This work has shown clear trends in prognosis for malaria in pregnancy and the difficulties in measuring birthweight, and these trends are likely to continue into the second trimester of pregnancy.

Improving early childhood growth and development in low- and middle-income countries: a randomized controlled trial of deworming incorporated into routine child health care in Peru

Overall, there was no statistically significant benefit of deworming on growth in this population of preschool-age children, however, the results do indicate that, for children between 12 and 24 months of age, once-yearly de worming at 12 years of age provides the greatest growth benefits compared to later or more frequent dewormed.

Effects of deworming on child and maternal health: a literature review and meta-analysis

Deworming did not show consistent benefits for indicators of mortality, anemia, or growth in children younger than five or women of reproductive age, and it is recommended not to include the effect of deworming in the LiST model.

Community-based interventions for the prevention and control of helmintic neglected tropical diseases

The meta-analysis suggests that CBIs are effective in reducing the prevalence of STH, and the qualitative synthesis from the included studies supports community-based delivery strategies and suggests that integrated prevention and control measures are more effective in achieving greater coverage compared to the routine vertical delivery, albeit it requires an existing strong healthcare infrastructure.

Empowering Women and Improving Female Reproductive Health through Control of Neglected Tropical Diseases

  • P. Hotez
  • Medicine
    PLoS neglected tropical diseases
  • 2009
This editorial examines the correlation between the control of neglected tropical diseases (NTDs) and women particularly those living in low-income countries. It focuses on the impact of NTDs on



Albendazole therapy and reduced decline in haemoglobin concentration during pregnancy (Sierra Leone).

  • H. TorlesseM. Hodges
  • Medicine
    Transactions of the Royal Society of Tropical Medicine and Hygiene
  • 2001

Hookworm infection in pregnancy.

Low birthweight and acute childhood diarrhoea: evidence of their association in an urban settlement of Papua New Guinea.

Greater attention should be paid to reducing the incidence of low birthweight, because such a reduction will not only be of benefit in the control of diarrhoea, but will also alleviate other factors which contribute to infant morbidity and mortality.

Zinc supplementation: effects on the growth and morbidity of undernourished Jamaican children

Zinc supplementation reduced the hospitalizations which probably reflect severity of morbidity, but did not improve growth, while the adequately nourished children were from significantly better socio-economic circumstances.

Zinc supplementation, mental development and behaviour in low birth weight term infants in northeast Brazil

Zinc supplementation for eight weeks may reverse some of the poor behaviours, particularly responsiveness, exhibited by low birth weight infants, but no amelioration of their mental and psychomotor deficits was found.

Iron fortification and iron supplementation are cost-effective interventions to reduce iron deficiency in four subregions of the world.

It is concluded that iron fortification is economically more attractive than iron supplementation, however, spending the extra resources to implement iron supplementation is still a cost-effective option.

Mass drug treatment for lymphatic filariasis and onchocerciasis.

Low birth weight and morbidity from diarrhea and respiratory infection in northeast Brazil.