A double‐blind, placebo‐controlled randomized trial of Serratulae quinquefoliae folium, a new source of β‐arbutin, in selected skin hyperpigmentations

  title={A double‐blind, placebo‐controlled randomized trial of Serratulae quinquefoliae folium, a new source of $\beta$‐arbutin, in selected skin hyperpigmentations},
  author={Monika Morąg and Jan Nawrot and Idzi Siatkowski and Zygmunt Adamski and Tomasz Fedorowicz and Renata Dawid-Pa{\'c} and Maria Urbańska and Gerard Nowak},
  journal={Journal of Cosmetic Dermatology},
Arbutin is one of the most effective lightening substances. Serratula quinquefolia is a new source of its β‐anomer. The HPLC method showed that the solid content of this compound in the dried plant raw material accounts for 6.86%. The leaves of Serratula quinquefolia do not contain hydroquinone. 

Phytotherapy Perspectives for Treating Fungal Infections, Migraine, Sebhorreic Dermatitis and Hyperpigmentations with the Plants of the Centaureinae Subtribe (Asteraceae)

The aim of the study was to describe recent studies in the field of phytotherapy, focusing on compounds isolated from chosen plants of Centaureinae and the possibilities of using them to treat antifungal infections, inhibit serotonin and ease symptoms of seborrhea dermatitis and hyperpigmentation.

Enhancement of Melanogenic Inhibitory Effects of the Leaf Skin Extracts of Aloe barbadensis Miller by the Fermentation Process

This work first showed that the skin-lightening effects of the leaf skin extracts of Aloe vera were significantly increased by the fermentation of Lactobacillus plantarum BN41. The fermented extract

Efficacy and Safety of Topical Therapy With Botanical Products for Melasma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

A systematic review and meta-analysis was conducted on the efficacy and safety of topical botanical products for the treatment of melasma, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), representing the best level of evidence currently available on topical use ofBotanical products on melasma.

Biologically Active Compounds in Stizolophus balsamita Inflorescences: Isolation, Phytochemical Characterization and Effects on the Skin Biophysical Parameters

It was revealed that S. balsamita extract might decrease TEWL level and fixed the barrier function of the epidermis, which makes them a valuable and safe source for creating new cosmetics and medicines.

Various Plants and Bioactive Constituents for Pigmentation Control: A Review

Use of plant-derived agents for the treatment of hyperpigmentation disorders is promising with the need for more rigorous clinical studies to support the use of these agents.

A systematic review of randomized controlled trials assessing phytochemicals and natural ingredients for skin and hair care

This paper systematically reviews randomized controlled trials investigating plant extracts, herbal preparations, and isolated plant-derived compounds used particularly for skin and hair care, finding some plants were found to have promising findings requiring further investigations in bigger RCTs with robust design and adequate reporting.

The Safety of Medicinal Plants Used in the Treatment of Vitiligo and Hypermelanosis: A Systematic Review of Use and Reports of Harm

  • I. Hussain
  • Medicine
    Clinical, cosmetic and investigational dermatology
  • 2021
The general protocol of clinical trials requires the screening of drugs/medicinal plants on the basis of safety studies before testing the clinical aspects of efficacy, so it is recommended that efficacy studies may be followed once the safety has been established for a particular medicinal plant in treating vitiligo and hypermelanosis.

The top 10 cosmeceuticals for facial hyperpigmentation

Possible safer and more efficacious cosmeceutical therapies the authors discuss include thiamidol, kojic acid, vitamin C, arbutin, retinol, nicotinamide, ferulic acid, resorcinol, licorice root extract, and soy.

Emerging topical therapies to treat pigmentary disorders: an evidence-based approach

Varying levels of evidence support the use of topicals in treating hyperpigmentation, and careful monitoring and adjustment of doses will be needed to maximize skin lightening benefits and minimize side effects.

Melasma Treatment: An Evidence-Based Review

Hydroquinone monotherapy and triple combination cream are the most effective and well-studied treatments for melasma, whereas chemical peels and laser- and light-based therapies are equal or inferior to topicals, but offer a higher risk of adverse effects.



Effect of arbutin on melanogenic proteins in human melanocytes.

Western blotting experiments revealed there were no changes in protein content or in molecular size of tyrosinase, TRP-1 orTRP-2, indicating that inhibition of tyosinase activity by arbutin might be due to effects at the post-translational level.

Arbutin: mechanism of its depigmenting action in human melanocyte culture.

  • K. MaedaM. Fukuda
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1996
The results suggest that the depigmenting mechanism of arbutin in humans involves inhibition of melanosomal tyrosinase activity, rather than suppression of the expression and synthesis of tyrosIn enzyme, which is effective in the topical treatment of various cutaneous hyperpigmentations characterized by hyperactive melanocyte function.

Skin lightening preparations and the hydroquinone controversy

Alternative agents to inhibit skin pigmentation such as retinoids, mequinol, azelaic acid, arbutin, kojic Acid, aleosin, licorice extract, ascorbic acid and N‐acetyl glucosamine are examined as possible topical alternatives to hydroquinone.

Improved quality of life with effective treatment of facial melasma: the pigment trial.

An open-label, community-based trial was undertaken at 393 centers in the United States, enrolling 1290 patients representing a broad range of races/ethnicities and all Fitzpatrick skin types, to evaluate the efficacy and safety of a new melasma treatment that combines fluocinolone acetonide 0.01%, hydroquinone 4.0%, and tretinoin 0.05% (FA+HQ+RA) in a hydrophilic cream formulation.

Management of Facial Hyperpigmentation

Melasma (chloasma) is the most common cause of facial pigmentation, but there are many other forms such as Riehl’s melanosis, poikiloderma of Civatte, erythrose peribuccale pigmentaire of Brocq, and cosmetic hyperpigmentations.

The use of botanical extracts as topical skin-lightening agents for the improvement of skin pigmentation disorders.

An overview of trends in the application of plant extracts as topical treatments for hyperpigmentation disorders is presented, providing in vitro screening results and relevant available clinical study trial findings supporting their efficacy.