A dose-response study in animals to evaluate the anticoagulant effect of the stage 2 unfractionated heparin USP monograph change.

@article{Honchel2011ADS,
  title={A dose-response study in animals to evaluate the anticoagulant effect of the stage 2 unfractionated heparin USP monograph change.},
  author={Ronald Honchel and Jeff Carraway and Neerunjun Gopee and Ralph J Callicott and Jiajie Chen and Robert Patton and Qing-Song Xu and J Zalkkar and Adebayo A. Laniyonu and Ira Krefting and Michael Cato and Kathy Robie-Suh and R Rieves},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2011},
  volume={60 3},
  pages={
          318-22
        }
}
The United States Pharmacopeia (USP) monograph for unfractionated heparin (UFH) was revised in October 2009. This revision was anticipated, based upon in vitro tests, to reduce UFH potency by approximately 10%. To study the potential in vivo consequences of the monograph change, we evaluated activated partial thromboplastin time (aPTT) and activated clotting time (ACT) responses in animals. Female mini-pigs and monkeys (n=8/species) were administered intravenously 60, 54, 48, or 42 U/kg and 50… CONTINUE READING