A dose-effect study of the in vivo inhibitory effect of quinidine on sparteine oxidation in man.

@article{Nielsen1990ADS,
  title={A dose-effect study of the in vivo inhibitory effect of quinidine on sparteine oxidation in man.},
  author={Mary Nielsen and Kim Br{\o}sen and Lars Freng Gram},
  journal={British journal of clinical pharmacology},
  year={1990},
  volume={29 3},
  pages={
          299-304
        }
}
1. Twelve healthy extensive metabolisers of sparteine were sparteine tested daily for 6 days (19.00 h to 07.00 h). A small but statistically significant rise in sparteine metabolic ratio (MR) was observed. 2. Following 100 mg quinidine sulphate given to four of the subjects at 16.00 h, sparteine tests were carried out 19.00 h to 07.00 h on the same day and then daily for 6 days. Quinidine caused an immediate twenty-fold increase in sparteine-MR which then gradually returned to normal over the… CONTINUE READING

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