A dose-defining study of sumatriptan suppositories in the acute treatment of migraine.

@article{Bertin1999ADS,
  title={A dose-defining study of sumatriptan suppositories in the acute treatment of migraine.},
  author={Lucille Bertin and Nils Brion and Markus F{\"a}rkkil{\"a} and Hartmut Goebel and Peter Wessely},
  journal={International journal of clinical practice},
  year={1999},
  volume={53 8},
  pages={593-8}
}
In this dose-ranging, randomised, multinational, multicentre, double-blind, placebo-controlled, parallel group study, 431 patients treated a single migraine attack with study medication: sumatriptan suppository 6 mg, 12.5 mg, 25 mg, 50 mg, 100 mg, or placebo. Patients were treated in the clinic with a single dose in suppository form. All doses of sumatriptan, except 6 mg, were significantly better than placebo (p < 0.004) and achieved similar rates of headache relief within two hours of dosing… CONTINUE READING

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