A dose–response study of nitric oxide synthase inhibition in different vascular beds in man

  title={A dose–response study of nitric oxide synthase inhibition in different vascular beds in man},
  author={Lisbeth Hjorth Lassen and Helle Klingenberg Iversen and J. Olesen},
  journal={European Journal of Clinical Pharmacology},
  • Lisbeth Hjorth Lassen, Helle Klingenberg Iversen, J. Olesen
  • Published 2003
  • Medicine
  • European Journal of Clinical Pharmacology
  • Background and objectiveNitric oxide (NO) is an almost ubiquitous messenger molecule and is implicated in several disorders. NG monomethyl l-arginine (l-NMMA:546C88) is an inhibitor of all three NO synthases (NOS), the enzymes that catalyse the production of NO. The present study was performed to evaluate the dose-response relation of l-NMMA to improve the design and interpretation of studies in migraine sufferers and other diseases.MethodsIn a double-blind, placebo-controlled, cross-over… CONTINUE READING
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