A dose–response study of nitric oxide synthase inhibition in different vascular beds in man

@article{Lassen2003ADS,
  title={A dose–response study of nitric oxide synthase inhibition in different vascular beds in man},
  author={Lisbeth Hjorth Lassen and Helle K. Iversen and Jes Olesen},
  journal={European Journal of Clinical Pharmacology},
  year={2003},
  volume={59},
  pages={499-505}
}
Nitric oxide (NO) is an almost ubiquitous messenger molecule and is implicated in several disorders. NG monomethyl l-arginine (l-NMMA:546C88) is an inhibitor of all three NO synthases (NOS), the enzymes that catalyse the production of NO. The present study was performed to evaluate the dose-response relation of l-NMMA to improve the design and interpretation of studies in migraine sufferers and other diseases. In a double-blind, placebo-controlled, cross-over design, six healthy volunteers were… CONTINUE READING

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