A dose–response meta-analysis of dietary lutein and zeaxanthin intake in relation to risk of age-related cataract

  title={A dose–response meta-analysis of dietary lutein and zeaxanthin intake in relation to risk of age-related cataract},
  author={Le Ma and Zhen-xuan Hao and Ru-ru Liu and Rong-bin Yu and Qiang Shi and Jian-ping Pan},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
BackgroundLutein and zeaxanthin are thought to have beneficial effects on protecting the lens against cataract formation, but findings from epidemiologic studies have been inconsistent. We aimed to conduct a meta-analysis of prospective cohort studies to examine the association between dietary lutein and zeaxanthin intake and risk of age-related cataract (ARC).MethodsWe systematically searched MEDLINE, EMBASE, Web of Science, and Cochrane Library databases up to March 2013. Reference lists from… 

Association between dietary carbohydrate intake and dietary glycemic index and risk of age-related cataract: a meta-analysis.

The results indicate that higher dietary carbohydrate quantity and GI may be associated with the risk of cortical and nuclear cataract, respectively.

Fruit, vegetable, and dietary antioxidant intake and age-related cataract risk: A case-control study

High daily intakes of fruit and vegetables and some dietary antioxidants might be associated with a decrease of cataract risk in Tehran, Iran.

Association Between Dietary Carbohydrate Intake and Dietary Glycemic Index and Risk of Age-Related Cataract:

It is indicated that higher dietary carbohydrate quantity and GI may be associated with the risk of cortical and nuclear cataract, respectively.

Dietary guidance for lutein: consideration for intake recommendations is scientifically supported

Based on a review of the literature supporting these criteria, lutein is ready to be considered for intake recommendations.

Physical activity and risk of age-related cataract.

The findings from this Meta-analysis provide additional evidence that increased physical activity is inversely associated with ARC risk dose-responsively and suggest that studies using metabolic equivalent per day tended to report a slightly stronger association with ARC.

Effect of Multiple Dietary Supplement Containing Lutein, 
Astaxanthin, Cyanidin-3-Glucoside, and DHA on Accommodative Ability

This study shows that multiple dietary supplement containing lutein, astaxanthin, cyanidin-3-glucoside, and DHA has effect to improve accommodative ability and subjective symptoms related to eye fatigue.

Lutein and Zeaxanthin Isomers in Eye Health and Disease.

  • J. Mares
  • Biology, Medicine
    Annual review of nutrition
  • 2016
Accumulating evidence about variable interindividual response to dietary intake of these carotenoids, based on genetic or metabolic influences, suggests that there may be subgroups that benefit from higher levels of intake and/or alternate strategies to improve lutein and zeaxanthin status.

Egyptian Vegetables as Source for Lutein and its Role in Incidence of Cataract in Rats

It is noticed that feeding on lutein diets increased the serum antioxidant enzymes and reduced the proteases activities in rats lenses compared with cataract group and thus its role in reducing the incidence ofCataract.



Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women's Health Initiative.

Diets rich in lutein and zeaxanthin are moderately associated with decreased prevalence of nuclear cataract in older women, and other protective aspects of such diets may in part explain these relationships.

Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study.

Higher dietary intakes of lutein/zeaxanthin and vitamin E from food and supplements were associated with significantly decreased risks of cataract in women from a large cohort of female health professionals.

Lutein/zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4.

Daily supplementation with lutein/zeaxanthin had no statistically significant overall effect on rates of cataract surgery or vision loss.

High-dose supplements of vitamins C and E, low-dose multivitamins, and the risk of age-related cataract: a population-based prospective cohort study of men.

The results suggest that the use of high-dose (but not low-dose) single vitamin C or E supplements may increase the risk of age-related cataract, and the risk may be even higher among older men, corticosteroid users, and long-term users.

Antioxidant nutrient intake and the long-term incidence of age-related cataract: the Blue Mountains Eye Study.

Higher intakes of vitamin C or the combined intake of antioxidants had long-term protective associations against development of nuclear cataract in this older population.

Lutein and zeaxanthin and the risk of cataract: the Melbourne visual impairment project.

An inverse association between high dietary LZ intake and prevalence of nuclear cataract is found and is similar to that found in previous studies of cortical, nuclear, and PSC cataracts.

Prospective study showing that dietary vitamin C reduced the risk of age-related cataracts in a middle-aged Japanese population

Dietary vitamin C intake might lower the risk of age-related cataracts among middle-aged Japanese and the effects of dietary antioxidants in an Asian population is studied.

Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study.

Results of this short term follow-up study are consistent with a possible protective influence of lutein and vitamins E and C on the development of nuclear cataracts, but evidence in the present study provides weak support for these associations.

Lutein / Zeaxanthin for the Treatment of Age-Related Cataract AREDS 2

RESULTS A total of 3159 AREDS2 participants were phakic in at least 1 eye and 1389 of 6027 study eyes underwent cataract surgery during the study, with median follow-up of 4.7 years. The 5-year

Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities.

A role for vitamin C in diminishing the risk of cortical cataracts in women aged <60 y and for carotenoid intake in women who have never smoked is supported.