A dose‐ranging study of the effects of mequitazine on actual driving, memory and psychomotor performance as compared to dexchlorpheniramine, cetirizine and placebo

@article{Theunissen2004ADS,
  title={A dose‐ranging study of the effects of mequitazine on actual driving, memory and psychomotor performance as compared to dexchlorpheniramine, cetirizine and placebo},
  author={Eef L Theunissen and Annemiek Vermeeren and Anita C M Van Oers and I van Maris and Johannes G Ramaekers},
  journal={Clinical \& Experimental Allergy},
  year={2004},
  volume={34}
}
Background Mequitazine is a so‐called ‘non‐sedative’ second‐generation antihistamine even though it has never been firmly established that this drug's sedative potential actually differs from that of the ‘sedative’ first‐generation antihistamines. 
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References

SHOWING 1-10 OF 67 REFERENCES
Does cetirizine belong to the new generation of antihistamines? An investigation into its acute and subchronic effects on highway driving, psychometric test performance and daytime sleepiness
TLDR
Twenty‐seven healthy male volunteers participated in a double‐blind, five‐way crossover designed comparison of the new, selective H1‐receptor antagonist cetirizine and terfenadine versus the older H1-receptor antagonists triprolidine and placebo.
Quantitative effects of cetirizine and diphenhydramine on mental performance measured using an automobile driving simulator.
TLDR
Data indicate that these doses of cetirizine produce little or no effect on cognitive function or mental performance, and diphenhydramine produced impaired mental performance and drowsiness.
Sedation and antihistamines: a review of inter‐drug differences using proportional impairment ratios
TLDR
A complete evaluation of sedation should be performed through standardised objective and subjective tests, shown to be sensitive to the central effects of AHs.
A placebo-controlled assessment of mequitazine and astemizole in tests of psychomotor ability.
TLDR
None of the treatments produced any significant or consistent effects when assessed on objective and subjective measures of performance, critical flicker fusion threshold, sedation and sleep and there were no treatment differences in the nature and number of adverse effects reported.
The Acute and Sub-chronic Effects of Levocetirizine, Cetirizine, Loratadine, Promethazine and Placebo on Cognitive Function, Psychomotor Performance, and Weal and Flare
TLDR
In a study where the psychometric assessments were shown to be sensitive to impairment, l-CTZ 5 mg was found not only to be a potent inhibitor of the histamine-induced weal and flare reaction, but also to show evidence of potent peripheral inhibition of histamine.
Effects of mefloquine alone and with alcohol on psychomotor and driving performance
TLDR
Mefloquine did not impair driving performance but rather improved it in the longer test, suggesting that the drug may possess psychostimulating properties.
Differentiating the effects of centrally acting drugs on arousal and memory: an event-related potential study of scopolamine, lorazepam and diphenhydramine
TLDR
It is concluded that benzodiazepines and anticholinergic drugs both reduce arousal and induce amnesia, but these effects are not interdependent.
Acute and subchronic effects of the H1-histamine receptor antagonist ebastine in 10, 20 and 30 mg dose, and triprolidine 10 mg on car driving performance.
TLDR
The results suggest that ebastine in doses up to 30 mg may be relatively safe for use by those who drive motor vehicles while under medication, and the results do not warrant such a conclusion for triprolidine 10 mg.
Antihistamine effects on actual driving performance in a standard test: a summary of Dutch experience, 1989‐94
The review summarizes the major results of eight double‐blind, placebo‐controlled, volunteer studies undertaken by three independent institutions for showing the effects on actual driving performance
The clinical safety of H1‐receptor antagonists: An EAACI position paper *
TLDR
Since antihistamines are used to treat non-life-threatening disorders, their risk/benefit ratio must be carefully evaluated and the safety issue is of central importance because of the widespread use of antihistamine in current medical practice.
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