A dorso-ventral shift of embryonic primordia in a new maternal-effect mutant of Drosophila

  title={A dorso-ventral shift of embryonic primordia in a new maternal-effect mutant of Drosophila},
  author={Christiane N{\"u}sslein-Volhard and Margit Lohs-Schardin and Klaus Sander and Christoph Cremer},
Mutations altering the spatial pattern of embryonic primordia are valuable tools for studying the earliest steps of embryonic pattern formation. As the spatial organisation of the egg cell arises during oogenesis, such mutants are likely to affect the embryo via the maternal genome (maternal effect). In Drosophila, most maternal-effect mutants studied so far lead to early developmental arrest. A few others yield pattern defects apparently linked to local failure of blastodermal cellularisation… 

Developmental analysis of fs(1)gastrulation defective, a dorsal-group gene of Drosophila melanogaster

Intermediate phenotypes suggested that cell interactions or movements associated with morphogenesis are required for the determination of some cell fates in the dorsoventral axis, suggesting that the developmental fate of all blastoderm cells may not be fixed at the time ofblastoderm formation.

Maternal-Zygotic Gene Interactions during Formation of the Dorsoventral Pattern in Drosophila Embryos.

A zygotic action for the dl gene in addition to the maternal effect was revealed by the finding that extra doses of dl(+) in the zygotes can partially rescue the dominant lethality ofheterozygous twi embryos derived from heterozygous dl females at high temperature.

Maternal-effect mutations altering the anterior-posterior pattern of the Drosophila embryo

Analysis of embryos derived from double mutant mothers suggests that these three phenotypic groups of mutants interfere with three different, independent pathways, which seem to act additively on the system which specifies anterior-posterior cellular fates within the egg.

cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos.

It is shown that in contrast to the dorsal group genes, the maternal gene cactus acts as a negative regulator of the nuclear localization of the dorsal protein, and the inhibitory function that cactus product exerts on the nuclear transport ofThe dorsal protein appears to be antagonized on the ventral side.

The decapentaplegic gene is required for dorsal-ventral patterning of the Drosophila embryo.

A novel embryonic function encoded by dppHin+ alleles of the dpp gene is defined, which is an early-acting, strictly zygotic function involved in establishing the embryonic dorsal-ventral pattern in Drosophila melanogaster.

Genes that control dorsoventral polarity affect gene expression along the anteroposterior axis of the Drosophila embryo.

Results indicate that cells respond to dorsoventral positional information in establishing early patterns of gene expression along the anteroposterior axis and that there may be more significant interactions between the different axes of positional information than previously determined.

Genetic and Developmental Approaches to Understanding Determination in Early Development

Experimental evidence relating to the stage of determination of blastoderm cells of the Drosophila melanogaster embryo is reviewed, indicating that mesodermal and endodermal precursors of both the larva and adult are undetermined with respect to segmental identity or tissue specificity at Blastoderm.