A dopamine transport inhibitor with markedly low abuse liability suppresses cocaine self-administration in the rat

@article{Ferragud2009ADT,
  title={A dopamine transport inhibitor with markedly low abuse liability suppresses cocaine self-administration in the rat},
  author={A. Ferragud and Clara Vel{\'a}zquez-S{\'a}nchez and V. Hern{\'a}ndez-Rabaza and A. N{\'a}cher and V. Merino and M. Card{\'a} and J. Murga and J. J. Canales},
  journal={Psychopharmacology},
  year={2009},
  volume={207},
  pages={281-289}
}
  • A. Ferragud, Clara Velázquez-Sánchez, +5 authors J. J. Canales
  • Published 2009
  • Medicine, Psychology
  • Psychopharmacology
  • RationaleN-substituted benztropine analogs are potent dopamine uptake inhibitors that display pharmacokinetic/dynamic properties consistent with the profile of a substitute medication for cocaine addiction.ObjectivesThe purpose of the present experiments was to characterize in rats the addictive-like properties of one such analog, 3α-[bis(4′-fluorophenyl)methoxy]-tropane (AHN-1055), incorporating probes of its stimulant and incentive/motivational effects and of its ability to influence cocaine… CONTINUE READING

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