A dopamine transport inhibitor with markedly low abuse liability suppresses cocaine self-administration in the rat

@article{Ferragud2009ADT,
  title={A dopamine transport inhibitor with markedly low abuse liability suppresses cocaine self-administration in the rat},
  author={Antonio Ferragud and Clara Vel{\'a}zquez-S{\'a}nchez and Vicente Hern{\'a}ndez-Rabaza and Amparo N{\'a}cher and V. Baonza Merino and Miguel Card{\'a} and Juan Murga and Juan Jose Canales},
  journal={Psychopharmacology},
  year={2009},
  volume={207},
  pages={281-289}
}
N-substituted benztropine analogs are potent dopamine uptake inhibitors that display pharmacokinetic/dynamic properties consistent with the profile of a substitute medication for cocaine addiction. The purpose of the present experiments was to characterize in rats the addictive-like properties of one such analog, 3α-[bis(4′-fluorophenyl)methoxy]-tropane (AHN-1055), incorporating probes of its stimulant and incentive/motivational effects and of its ability to influence cocaine self… CONTINUE READING

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