A domino approach to the enantioselective total syntheses of blennolide C and gonytolide C.


The first enantioselective total syntheses of the tetrahydroxanthenone (-)-blennolide C (ent-4) and related γ-lactonyl chromanone (-)-gonytolide C (ent-3) are reported. Key to the syntheses is an enantioselective domino-Wacker/carbonylation/methoxylation reaction to set up the stereocentre at C-4a. Various chiral BOXAX ligands were investigated, including… (More)
DOI: 10.1002/chem.201402495


  • Presentations referencing similar topics