A dominant role of acid pH in inflammatory excitation and sensitization of nociceptors in rat skin, in vitro

@inproceedings{Steen1995ADR,
  title={A dominant role of acid pH in inflammatory excitation and sensitization of nociceptors in rat skin, in vitro},
  author={K. H. Steen and A E Steen and Peter W. Reeh},
  booktitle={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1995}
}
A major role of local acidosis in long lasting excitation and sensitization of cutaneous nociceptors has recently been demonstrated. In inflamed tissue, acid pH meets with a mixture of inflammatory mediators which, by themselves, stimulate nociceptors though being subject to profound tachyphylaxis. We have mimicked this condition in a rat skin-saphenous nerve preparation in vitro which allows direct application of chemicals to the isolated receptive fields at the corium side. Stimulant… Expand
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TLDR
A striking feature of pH-induced pain and nociceptor excitation is the synergism with mediators of inflammation encountered with tissue acidosis in inflamed areas, which occurs upon repeated or prolonged exposure to low pH. Expand
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Interactions of inflammatory mediators and low pH not influenced by capsazepine in rat cutaneous nociceptors
The rat skin-saphenous nerve preparation was used to record from mechano-heat sensitive C-fibers whose receptive fields were superfused with various solutions of low pH and of bradykinin, serotoninExpand
Inflammatory mediators at acidic pH activate capsaicin receptors in cultured sensory neurons from newborn rats.
TLDR
It is suggested that the inflammatory mediators, bradykinin,5-HT, and prostaglandin E2 together act as endogenous mediators at capsaicin receptors to generate an inward current when the ion channel is protonized. Expand
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