A dominant role of Toll-like receptor 4 in the signaling of apoptosis in bacteria-faced macrophages.

@article{Haase2003ADR,
  title={A dominant role of Toll-like receptor 4 in the signaling of apoptosis in bacteria-faced macrophages.},
  author={Rudolf Haase and Carsten J Kirschning and A Shum Cheong Sing and Percy Schroettner and Koichi Fukase and Shoichi Kusumoto and Hermann Wagner and Juergen Heesemann and Klaus Ruckdeschel},
  journal={Journal of immunology},
  year={2003},
  volume={171 8},
  pages={4294-303}
}
Conserved bacterial components potently activate host immune cells through transmembrane Toll-like receptors (TLRs), which trigger a protective immune response but also may signal apoptosis. In this study, we investigated the roles of TLR2 and TLR4 as inducers of apoptosis in Yersinia enterocolitica-infected macrophages. Yersiniae suppress activation of the antiapoptotic NF-kappaB signaling pathway in host cells by inhibiting inhibitory kappaB kinase-beta. This leads to macrophage apoptosis… CONTINUE READING
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