A dominant role of GTRAP3-18 in neuronal glutathione synthesis.

@article{Watabe2008ADR,
  title={A dominant role of GTRAP3-18 in neuronal glutathione synthesis.},
  author={Masahiko Watabe and Koji Aoyama and Toshio Nakaki},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 38},
  pages={9404-13}
}
Glutathione is an essential reductant which protects cells and is reduced in neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. Neurons rely mainly on extracellular cysteine for glutathione synthesis and a cysteine transporter termed excitatory amino acid carrier 1 (EAAC1). However, the mechanisms underlying neuronal cysteine uptake have remained elusive. Herein, we show glutamate transport-associated protein for EAAC1 (GTRAP3-18) to interact with EAAC1 at the plasma… CONTINUE READING

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