A dominant role for FE65 (APBB1) in nuclear signaling.

  title={A dominant role for FE65 (APBB1) in nuclear signaling.},
  author={Zheng Yang and Bethany H. Cool and George M. Martin and Qubai Hu},
  journal={The Journal of biological chemistry},
  volume={281 7},
FE65 has been described as an adaptor protein; its partners include the beta-amyloid precursor protein (APP) and Tip60 (a histone acetyltransferase). Recent evidence suggests that APP may function in a nuclear signaling pathway via formation of APP-FE65-Tip60 complexes. The evidence is largely based on experiments in which APP/Tip60 is fused to the DNA binding domain of a yeast transcriptional factor Gal4 (Gal4DB) that can activate a reporter gene only when FE65 is coexpressed. One… CONTINUE READING


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