A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.

@article{Dunn1998ADN,
  title={A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.},
  author={Sandra E. Dunn and Melanie Ehrlich and Nicholas J. Sharp and Krzysztof Reiss and Gabriel Solomon and Robert Hawkins and Renato Baserga and Jeffrey C. Barrett},
  journal={Cancer research},
  year={1998},
  volume={58 15},
  pages={3353-61}
}
The 5-year survival rate for women with metastatic breast cancer is only 25-30%; thus, the need to improve treatment is apparent. Overexpression of insulin-like growth factor-I receptor (IGF-IR) correlates with poor prognosis and local recurrence. In this study, we addressed whether functional impairment of IGF-IR affects adhesion, invasion, and metastasis of breast cancer. Impairment of IGF-IR function was achieved by transfecting a dominant negative form of the receptor, termed 486stop, into… CONTINUE READING

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Insulin-like growth factor-I alters drug sensitivity of human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs

  • Dunn, R S.E..Hardman., W Kari.F., Barrett, C J.
  • Cancer Res.
  • 1997
Highly Influential
3 Excerpts

The roles of integrins and extracellular matrix proteins in the insulin-like growth factor-1 stimulated chemotaxis of human breast cancer cells

  • Doerr, E M., I Jones.J.
  • J. Biol. Chem.,
  • 1996
Highly Influential
4 Excerpts

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