A dominant negative cadherin inhibits osteoblast differentiation.

  title={A dominant negative cadherin inhibits osteoblast differentiation.},
  author={S. L. Cheng and Chan Soo Shin and Dwight A Towler and Roberto Civitelli},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={15 12},
We have previously indicated that human osteoblasts express a repertoire of cadherins and that perturbation of cadherin-mediated cell-cell interaction reduces bone morphogenetic protein 2 (BMP-2) stimulation of alkaline phosphatase activity. To test whether inhibition of cadherin function interferes with osteoblast function, we expressed a truncated N… CONTINUE READING