A domain of Rad9 specifically required for activation of Chk1 in budding yeast.

@article{Blankley2004ADO,
  title={A domain of Rad9 specifically required for activation of Chk1 in budding yeast.},
  author={Richard T. Blankley and David Lydall},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 4},
  pages={601-8}
}
The Rad9 protein is a key adaptor protein in Saccharomyces cerevisiae DNA damage checkpoint pathways. Its adaptor function is to link the activity of the Mec1 kinase to the activation of two parallel signalling pathways dependent on the Rad53 and Chk1 kinases. The mechanisms by which Rad9 interacts with, and activates, Rad53 are well understood. However, little was known about how Rad9 facilitates the activation of Chk1. We show here that the N-terminus of Rad9 is specifically important for… CONTINUE READING

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