A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells.

@article{Tangye2003ADM,
  title={A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells.},
  author={Stuart G Tangye and Danielle T Avery and Philip D. Hodgkin},
  journal={Journal of immunology},
  year={2003},
  volume={170 1},
  pages={
          261-9
        }
}
Memory B cells, when re-exposed to Ag and T cell help, differentiate into Ig-secreting cells (ISC) at the same time as maintaining a residual pool of non-Ig-secreting cells with memory capabilities. To investigate the mechanism underlying this dual process, we followed the fate of human B cells activated in vitro with the T cell-derived signals CD40 ligand (CD40L), IL-2, and IL-10 using CFSE to monitor cell division. A substantial number of ISCs detected by ELISPOT, intracellular Ig staining… CONTINUE READING

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