A divergent transcription factor TFIIB in trypanosomes is required for RNA polymerase II-dependent spliced leader RNA transcription and cell viability.

@article{Palenchar2006ADT,
  title={A divergent transcription factor TFIIB in trypanosomes is required for RNA polymerase II-dependent spliced leader RNA transcription and cell viability.},
  author={Jennifer B Palenchar and Wen-Zhe Liu and Peter M. Palenchar and Vivian Bellofatto},
  journal={Eukaryotic cell},
  year={2006},
  volume={5 2},
  pages={
          293-300
        }
}
Transcription by RNA polymerase II in trypanosomes deviates from the standard eukaryotic paradigm. Genes are transcribed polycistronically and subsequently cleaved into functional mRNAs, requiring trans splicing of a capped 39-nucleotide leader RNA derived from a short transcript, the spliced leader (SL) RNA. The only identified trypanosome RNA polymerase II promoter is that of the SL RNA gene. We have previously shown that transcription of SL RNA requires divergent trypanosome homologs of RNA… CONTINUE READING

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