A divergent enantioselective strategy for the synthesis of griseusins.

  title={A divergent enantioselective strategy for the synthesis of griseusins.},
  author={Yinan Zhang and Qing Ye and Xiachang Wang and Qing-Bai She and Jon S. Thorson},
  journal={Angewandte Chemie},
  volume={54 38},
The first enantioselective total synthesis of griseusin A, griseusin C, 4'-deacetyl-griseusin A, and two non-native counterparts in 11-14 steps is reported. This strategy highlights a key hydroxy-directed CH olefination of 1-methylene isochroman with an α,β-unsaturated ketone followed by subsequent stereoselective epoxidation and regioselective cyclization to afford the signature tetrahydro-spiropyran ring. Colorectal cancer cell cytotoxicities of the final products highlight the impact of the… 
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