A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor.

Abstract

Caenorhabditis elegans contains a family of putative insulin-like genes proposed to regulate dauer arrest and senescence. These sequences often lack characteristic sequence features of human insulin essential for its folding, structure, and function. Here, we describe the structure and receptor-binding properties of INS-6, a single-chain polypeptide… (More)

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