A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

@article{LangeCarter1993ADI,
  title={A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf},
  author={Carol A. Lange-Carter and C M Pleiman and A M Gardner and KJ Blumer and G Johnson},
  journal={Science},
  year={1993},
  volume={260},
  pages={315 - 319}
}
Mitogen-activated protein kinases (MAPKs) are rapidly phosphorylated and activated in response to various extracellular stimuli in many different cell types. Such regulation of MAPK results from sequential activation of a series of protein kinases. The kinases that phosphorylate MAPKs, the MAP kinase kinases (MEKs) are also activated by phosphorylation. MEKs are related in sequence to the yeast protein kinases Byr1 (from Schizosaccharomyces pombe) and Ste7 (from Saccharomyces cerevisiae), which… 
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Cloning of a Novel Mitogen-activated Protein Kinase Kinase Kinase, MEKK4, That Selectively Regulates the c-Jun Amino Terminal Kinase Pathway*
TLDR
MEKK4 has a putative pleckstrin homology domain and a proline-rich motif, suggesting specific regulatory functions different from those of the previously characterized MEKKs.
Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade (*)
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MEK6 is a member of the p38 kinase cascade and efficiently phosphorylates p38 but not c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinases (ERK) family members in direct kinase assays.
The mitogen activated protein kinase signal transduction pathway: from the cell surface to the nucleus.
  • K. Guan
  • Biology, Chemistry
    Cellular signalling
  • 1994
Reconstitution of Mitogen-activated Protein Kinase Phosphorylation Cascades in Bacteria
TLDR
Three purified, active MAP kinases have specific activities in the range of 0.6-2.3 μmol/min/mg and are of great value in the preparation of numerous phosphoproteins, heretofore not possible in procaryotic expression systems.
Molecular Cloning and Characterization of a Novel Protein Kinase with a Catalytic Domain Homologous to Mitogen-activated Protein Kinase Kinase Kinase*
TLDR
The isolation of a cDNA encoding a novel protein kinase designated MAPKKK5 from a human macrophage library was reported, suggesting that MAPKKk5 may be an upstream activator of MKK4 in the c-Jun N-terminal kinase pathway.
Molecular Cloning of Mitogen-activated Protein/ERK Kinase Kinases (MEKK) 2 and 3
TLDR
A family of MEKK proteins capable of regulating sequential protein kinase pathways involving MAPK members is defined, which includes MEKK 2, MEK 1, and JNK kinase.
Ras-dependent growth factor regulation of MEK kinase in PC12 cells.
TLDR
Ras simultaneously controls the activation of members of the Raf and MEKK families of protein kinases and abolished activation of MEKK and B-Raf by EGF, NGF, and TPA.
Networking with mitogen-activated protein kinases
TLDR
Isoforms of all of the protein kinases may specifically combine to assemble distinct modules for intracellular signal transmission, however, the fundamental architecture of these protein kinase cascades has been highly conserved during eukaryotic evolution.
Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinase.
Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.
TLDR
All known MAPK module kinases from yeast to humans are defined, what is known about their regulation, defined MAPK substrates, and the function of MAPK in cell physiology are defined.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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