A dityrosine network mediated by dual oxidase and peroxidase influences the persistence of Lyme disease pathogens within the vector.

@article{Yang2014ADN,
  title={A dityrosine network mediated by dual oxidase and peroxidase influences the persistence of Lyme disease pathogens within the vector.},
  author={Xiuli Yang and Alexis A. Smith and Mark Thomas Shaw Williams and Utpal Pal},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 18},
  pages={
          12813-22
        }
}
Ixodes scapularis ticks transmit a wide array of human and animal pathogens including Borrelia burgdorferi; however, how tick immune components influence the persistence of invading pathogens remains unknown. As originally demonstrated in Caenorhabditis elegans and later in Anopheles gambiae, we show here that an acellular gut barrier, resulting from the tyrosine cross-linking of the extracellular matrix, also exists in I. scapularis ticks. This dityrosine network (DTN) is dependent upon a dual… CONTINUE READING
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