A distributed cell division counter reveals growth dynamics in the gut microbiota

@inproceedings{Myhrvold2015ADC,
  title={A distributed cell division counter reveals growth dynamics in the gut microbiota},
  author={Cameron Myhrvold and Jonathan W. Kotula and Wade M. Hicks and Nicholas J. Conway and Pamela A. Silver},
  booktitle={Nature communications},
  year={2015}
}
Microbial population growth is typically measured when cells can be directly observed, or when death is rare. However, neither of these conditions hold for the mammalian gut microbiota, and, therefore, standard approaches cannot accurately measure the growth dynamics of this community. Here we introduce a new method (distributed cell division counting, DCDC) that uses the accurate segregation at cell division of genetically encoded fluorescent particles to measure microbial growth rates. Using… CONTINUE READING
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