A distinctive role for focal adhesion proteins in three-dimensional cell motility

Abstract

Focal adhesions are large multi-protein assemblies that form at the basal surface of cells on planar dishes, and that mediate cell signalling, force transduction and adhesion to the substratum. Although much is known about focal adhesion components in two-dimensional (2D) systems, their role in migrating cells in a more physiological three-dimensional (3D… (More)
DOI: 10.1038/ncb2062

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